We had previously developed a deep-learning-based risk evaluation system from retinal photographs, Reti-CKD, for stratifying chronic kidney development risk in kidney function preserved people. This study aims to evaluate whether Reti-CKD can improve risk assessment of kidney disease progression in diabetic patients with prevalent CKD.<\/p>\n\n\n\n
Total of 5348 diabetic patients from two tertiary hospitals in Korea were evaluated. Patients with estimated glomerular filtration rate (eGFR) <90 ml\/min\/1.73m2<\/sup>\u00a0or albuminuria were included. Those with missing data for retinal photograph, serum creatinine, or albuminuria were excluded. Patients were categorized into low-risk, moderate-risk, and high-risk groups according to the KDIGO criteria for prognosis of CKD. The KDIGO groups were additionally dichotomized based on Reti-CKD score (Reti-CKD <20 and \u226520). CKD progression was compared between the categories using Cox regression models. Primary outcome was CKD progression, defined as incremental progression to a higher NKF-KDOQI CKD stage.<\/p>\n\n\n\n The mean age of the patients was 62.4 \u00b1 11.4 years and 60.6% were male. Mean eGFR was 86.6 \u00b1 15.3 mL\/min per 1.73 m2\u00a0<\/sup>and albuminuria was present in 46.9%. During a median follow-up of 5.0 (interquartile range, 2.5-7.8) years, primary outcome developed in 1379 (25.8%) patients. The primary outcome incidence rate gradually increased with higher KDIGO and Reti-CKD combined risk categories. The risk for CKD progression progressively increased in KDIG moderate-risk and high-risk groups compared to low-risk. When Reti-CKD was incorporated to the KDIGO category, significant stratification of CKD progression risk was noted in the KDIGO low-risk and moderate-risk groups. Additionally, the combination of KDIGO and Reti-CKD classification showed better discrimination power compared to the KDIGO only classification (delta c-statistics, 0.03; 95% CI 0.02 to 0.040).<\/p>\n\n\n\n Retinal photography-based deep learning system (Reti-CKD) further stratifies the risk of CKD progression and improves predictability in diabetic patients with reduced renal function.<\/p>\n","protected":false},"template":"","publication_type_categories":[12],"publication_categories":[17],"class_list":["post-1040","publication","type-publication","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/mediwhale.stage.studio-jt.co.kr\/ko\/wp-json\/wp\/v2\/publication\/1040","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mediwhale.stage.studio-jt.co.kr\/ko\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/mediwhale.stage.studio-jt.co.kr\/ko\/wp-json\/wp\/v2\/types\/publication"}],"version-history":[{"count":1,"href":"https:\/\/mediwhale.stage.studio-jt.co.kr\/ko\/wp-json\/wp\/v2\/publication\/1040\/revisions"}],"predecessor-version":[{"id":1041,"href":"https:\/\/mediwhale.stage.studio-jt.co.kr\/ko\/wp-json\/wp\/v2\/publication\/1040\/revisions\/1041"}],"wp:attachment":[{"href":"https:\/\/mediwhale.stage.studio-jt.co.kr\/ko\/wp-json\/wp\/v2\/media?parent=1040"}],"wp:term":[{"taxonomy":"publication_type_categories","embeddable":true,"href":"https:\/\/mediwhale.stage.studio-jt.co.kr\/ko\/wp-json\/wp\/v2\/publication_type_categories?post=1040"},{"taxonomy":"publication_categories","embeddable":true,"href":"https:\/\/mediwhale.stage.studio-jt.co.kr\/ko\/wp-json\/wp\/v2\/publication_categories?post=1040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Results<\/h4>\n\n\n\n
Conclusion<\/h4>\n\n\n\n